The present formulation study of paclitaxel was performed as an attempt to prepare BSA nanoparticulate drug delivery system using desolvation method with spray drying and performance of these formulations was evaluated. From the experimental results it was concluded that: Bovine serum albumin (BSA) is an ideal carrier for preparing nanoparticles of paclitaxel. The use of acetone consistently gave smaller particles as compared to ethanol for all BSA concentrations. Desolvated BSA nanoparticles have the stability problem hence glutaraldehyde (GTA) is used as cross-linking agent for the production of stable nanoparticles. GTA also affect the entrapment efficiency and release rate but had no influence on particle size. Tween 80 is non-ionic surfactant used as dispersing agent to form stable nanoparticles.
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